Human retinal pigment epithelium (RPE) transplantation: outcome after autologous RPE-choroid sheet and RPE cell-suspension in a randomised clinical study
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چکیده
منابع مشابه
A reply to human retinal pigment epithelium (RPE) transplantation: outcome after autologous RPE-choroid sheet and RPE cell-suspension in a randomised clinical study.
I took great interest in the recent article regarding the retinal pigment epithelium (RPE) transplantation by Falkner-Radler et al. I agree that RPE cell transplantation might be a novel therapeutic option for patients in the antivascular endothelial growth factor (anti-VEGF) era, where antiVEGF fails to improve visual acuity. This is the case in RPE tear, massive subretinal haemorrhage or anti...
متن کاملHuman retinal pigment epithelium (RPE) transplantation: outcome after autologous RPE-choroid sheet and RPE cell-suspension in a randomised clinical study.
AIMS To evaluate the outcome after two types of retinal pigment epithelium (RPE) transplantation techniques. METHODS Fourteen consecutive patients with advanced exudative age-related macular degeneration (AMD) were randomly assigned to RPE-choroid sheet transplantation (group 1) or RPE cell-suspension transplantation (group 2). Outcome measures included best corrected distance and near visual...
متن کاملAge-Related Changes in the Retinal Pigment Epithelium (RPE)
BACKGROUND Age-related changes in the retina are often accompanied by visual impairment but their mechanistic details remain poorly understood. METHODOLOGY Proteomic studies were pursued toward a better molecular understanding of retinal pigment epithelium (RPE) aging mechanisms. RPE cells were isolated from young adults (3-4 month-old) and old (24-25 month-old) F344BN rats, and separated int...
متن کاملmiR-146a is upregulated during retinal pigment epithelium (RPE)/choroid aging in mice and represses IL-6 and VEGF-A expression in RPE cells.
PURPOSE MicroRNA-146a (miR-146a) has been proposed as a marker for age-associated inflammation, or "inflammaging", acting as a negative regulator of cellular senescence and pro-inflammatory signaling pathways. However, the regulation and function of miR-146 during ocular aging remains unclear. Here we propose that miR-146 is regulated during aging of the retina and choroid, and functions in ret...
متن کاملCellular and Molecular Preconditions for Retinal Pigment Epithelium (RPE) Natural Reprogramming during Retinal Regeneration in Urodela
Many regeneration processes in animals are based on the phenomenon of cell reprogramming followed by proliferation and differentiation in a different specialization direction. An insight into what makes natural (in vivo) cell reprogramming possible can help to solve a number of biomedical problems. In particular, the first problem is to reveal the intrinsic properties of the cells that are nece...
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ژورنال
عنوان ژورنال: British Journal of Ophthalmology
سال: 2010
ISSN: 0007-1161
DOI: 10.1136/bjo.2009.176305